HKU5-CoV-2: A New Coronavirus Raising Global Concerns

Why in the News?

HKU5-CoV-2, a newly identified coronavirus, has drawn attention due to its genetic similarities with SARS-CoV-2 and MERS. Its ability to bind to human ACE2 receptors suggests a potential zoonotic threat, highlighting the need for global virus surveillance and preparedness.

HKU5-CoV-2: A New Coronavirus Raising Global Concerns

Overview and Characteristics:

  • HKU5-CoV-2 is a newly identified coronavirus that has raised concerns due to its genetic similarities with SARS-CoV-2.
  • It belongs to the merbecovirus subgenus, which also includes the MERS virus.
  • The virus has the ability to bind to human ACE2 receptors, though with a lower affinity compared to SARS-CoV-2.
  • Its potential for widespread human infection remains uncertain due to its weaker binding capacity.

Zoonotic Transmission Risks:

  • HKU5-CoV-2 can bind to ACE2 receptors in multiple mammalian species, raising concerns about cross-species transmission.
  • The possibility of the virus jumping to humans through an intermediate host remains a key area of research.
  • No human infections have been reported so far, and its symptoms are currently unknown.
  • The discovery was made by Shi Zhengli from the Wuhan Institute of Virology, known for her research on bat coronaviruses.

Need for Surveillance and Preparedness

  • While the immediate risk to humans is uncertain, HKU5-CoV-2 highlights the importance of monitoring zoonotic viruses.
  • Lessons from the COVID-19 pandemic emphasize the need for proactive surveillance and preparedness.
  • Global efforts should focus on early detection and research to mitigate potential future outbreaks.

About HKU5-CoV-2:

  • Newly discovered bat coronavirus with genetic similarities to SARS-CoV-2.
  • Belongs to the merbecovirus subgenus, which includes the MERS virus.
  • Capable of binding to human ACE2 receptors, indicating potential zoonotic transmission.
  • Has lower binding affinity to human ACE2 than SARS-CoV-2, making large-scale infection uncertain.
  • Can bind to ACE2 receptors in multiple mammalian species, suggesting possible transmission via an intermediate host.
  • No confirmed human cases yet; symptoms remain unknown.
  •  Discovered by Shi Zhengli’s team at the Wuhan Institute of Virology, China.